Study title and authors:
Mevastatin accelerates loss of synaptic proteins and neurite degeneration in aging cortical neurons in a heme-independent manner.
Kannan M, Steinert JR, Forsythe ID, Smith AG, Chernova T.
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MRC Toxicology Unit, University of Leicester, Leicester, United Kingdom.
This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/18951667
Kannan investigated the effectes of statins on cultured neurons.
The study found:
(a) Statins impaired synaptic proteins.
(b) Statins reduced N-methyl-d-aspartate receptor currents (N-methyl-d-aspartate receptor currents help in memory funcion).
(c) Statins accelerated neurodegeneration associated with aging.
To conclude: Statins exert a neurotoxic effect in cultured neurons and may be implicated in neurodegenerative diseases such as Parkinson’s, Alzheimer’s, Amyothrophic Lateral Sclerosis, Multiple Sclerosis and Huntington’s.
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