Study title and authors:
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Serum ubiquinone concentrations after short- and long-term treatment with HMG-CoA reductase inhibitors.
Laaksonen R, Ojala JP, Tikkanen MJ, Himberg JJ.Department of Clinical Pharmacology, University of Helsinki, Finland.
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/7957515
This study analysed the effect of long- and short-term statin treatment on the levels of ubiquinone (coenzyme Q10). The study included 17 men with "high" cholesterol who had their coenzyme Q10 levels were measured:
(i) After they had received simvastatin (20-40 mg per day) for 4.7 years.
(ii) After a 4 week treatment pause.
(iii) Again after they had resumed treatment with lovastatin (20-40 mg per day) for 12 weeks.
The study found:
(a) During the statin treatment pause the average coenzyme Q10 levels increased by 32%.
(b) Resumption of statin treatment caused a reduction of 25% in coenzyme Q10 levels.
Coenzyme Q10 is a nutrient that every cell in the body must have in order to produce energy. See here and here
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