The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Wednesday, 21 April 2010

Statins reduce Coenzyme Q10 by 40% and may cause cellular damage

This post includes a summary of a paper published in the Journal of Clinical Pharmacology 1993 Mar;33(3):226-9 and a recipe for pizza bites.

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Books:
Study title and authors:
Evidence of plasma CoQ10-lowering effect by HMG-CoA reductase inhibitors: a double-blind, placebo-controlled study.
Ghirlanda G, Oradei A, Manto A, Lippa S, Uccioli L, Caputo S, Greco AV, Littarru GP.
Institute of Internal Medicine, Catholic University Medical School, Rome, Italy.

This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/8463436

Concurrent to reducing cholesterol levels stain drugs also reduce the biosynthesis of the important nutrient ubiquinone (Coenzme Q10).

This study investigated the effects of statins on Coenzme Q10 levels. Firstly, two groups of five healthy volunteers treated with 20 mg per day of pravastatin  or simvastatin for a month. Then in a double-blind controlled study 30 patients with "high" cholesterol were given either pravastatin, simvastatin (20 mg per day), or placebo for three months.

The study found:
(a) In the healthy volunteer group cholesterol levels and Coenzme Q10 levels underwent about a 40% reduction after the statin treatment.
(b) The same extent of reduction, compared with placebo was measured in the "high" cholesterol patients treated with pravastatin or simvastatin.

The data show that the treatment with statins lowers both cholesterol and Coenzme Q10 levels in normal volunteers and in patients with "high" cholesterol.

The authors of the study, based at the Catholic University Medical School in Rome, concluded: "Coenzme Q10 is essential for the production of energy and also has antioxidative properties. A diminution of Coenzme Q10 availability may be the cause of membrane alteration with consequent cellular damage".

More information on this subject: Books : Scientific Studies : Other Websites : Videos : Food Mall 




Pizza Bites

Ingredients:
◦5-7 oz. (about 20-30 pieces) large, preservative-free pepperoni
All Natural, Nitrate Free Dry Cured Italian Style Pepperoni: 9oz. Pkg (2 Sticks Per Package)
Food Mall: Nitrate Free Pepperoni
◦pizza sauce
◦grated cheese, optional

For Supreme
◦black olives
◦bell peppers
◦mushrooms
◦green onions

For Hawaiian
◦deli ham
◦fresh pineapple

Method:
Get your oven to 400ÂșF. Lay the slices of pepperoni on a baking sheet and put them in the oven, on the middle rack, to get them crispy–about 8 minutes, flipping them over once. Start prepping your toppings while the peps are in the oven.

The pre-bake step of the pepperoni is super important if you want a crispy pepperoni “crust”. Once you top the pepperonis they just don’t crisp up much…

Once they come out of the oven, place a spoonful of pizza sauce on each pepperoni slice and top with your ingredients.

Place the baking sheet back in the oven and let the toppings get warm and melty, anywhere from 5-10 minutes.

NOTE: All the toppings should be sliced, chopped, and/or diced super, super small/thin. Since you’re making little petite pizzas and they’re only getting a few minutes of oven time, you want make sure they get enough heat to get them cooked through.