Hard scientific evidence of the effects of diet, pharmaceutical drugs & lifestyle on health from over 1,400 studies from research centers, universities and peer reviewed scientific journals.

Research by David Evans

Monday, 18 August 2014

Low cholesterol levels predict high death rates in the very elderly

This study was published in Clinical Interventions in Aging 2014 Feb 13;9:293-300

Study title and authors:
Serum total cholesterol concentration and 10-year mortality in an 85-year-old population.
Takata Y, Ansai T, Soh I, Awano S, Nakamichi I, Akifusa S, Goto K, Yoshida A, Fujii H, Fujisawa R, Sonoki K
Division of General Internal Medicine, School of Oral Health Science, Kyushu Dental College, Kitakyushu, Japan.

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/24611005

This study evaluated the effect of cholesterol levels with death rates in the very elderly. The study included 207 very elderly (85-year-old) participants who were followed for ten years. The participants were allocated into three groups:
(i) High cholesterol: more than 209 mg/dL (5.4 mmol/L)
(ii) Intermediate cholesterol: between 176-208 mg/dL (4.5-5.3 mmol/L)
(iii) Low cholesterol: less than 175 mg/dL (4.5 mmol/L)

The study found:
(a) The group with the lowest cholesterol levels had a 72% higher death rate compared to the group with the highest cholesterol.
(b) Death rates decreased by 0.9% with each 1 mg/dL increase in cholesterol levels.
(c) Death rates decreased by 0.8% with each 1 mg/dL increase in low density lipoprotein (LDL) cholesterol levels.
(d) Death rates decreased by 1.0% with each 1 mg/dL increase in high density lipoprotein (HDL) cholesterol levels.
(e) Death rates decreased by 0.3% with each 1 mg/dL increase in triglyceride levels.

Takata concluded: "These findings suggest that low TC (total cholesterol) and low LDL-C may be independent predictors of high mortality in the very elderly".

Thursday, 14 August 2014

Statins increase the risk of suicidal thoughts by 159%

This study was published in Crisis 2014 Jan 1;35(4):278-82

Study title and authors:
Lipophilic statin use and suicidal ideation in a sample of adults with mood disorders.
Davison KM, Kaplan BJ.
School of Nursing, University of British Columbia, Vancouver, BC, Canada Health Science Program, Kwantlen Polytechnic University, Surrey, BC, Canada

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/25113893

This study investigated the association between statins and suicidal ideation (suicidal thoughts) in adults with mood disorders. The study included 97 patients, aged over 18 years.

The study found those taking statins had a 159% increased prevalence of suicidal ideation compared to those not taking statins.

Friday, 8 August 2014

Statins increase the risk of Bell's palsy by 47%

This study was published in Drug Safety 2014 Jul 31
 
Study title and authors:
Association Between Statin Use and Bell's Palsy: A Population-Based Study
Hung SH, Wang LH, Lin HC, Chung SD.
Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan.
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/25079142

This study aimed to evaluate the association between statin use and Bell's palsy. This case-control study identified 1,977 subjects with Bell's palsy as cases and 5,931 sex- and age-matched subjects without Bell's palsy.

The study found that statin users had a 47% increased risk of Bell's palsy compared to non-users.

Saturday, 2 August 2014

The association between statins and thyroid cancer

This study was published in Clinical Endocrinology (Oxf) 2014 Jul 30
 
Study title and authors:
Statin Use and Thyroid Cancer: A Population-Based Case-Control Study.
Hung SH, Lin HC, Chung SD.
Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan.
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/25074346

This study aimed to evaluate the association of statin use with thyroid cancer. The study included 500 subjects with thyroid cancer as cases and 2,500 gender- and age-matched subjects without thyroid cancer as controls.

The study found:
(a) Women who used statins had a 43% increased risk of thyroid cancer compared to women not taking statins.
(b) Men who used statins had a 28% increased risk of thyroid cancer compared to men not taking statins.

Thursday, 31 July 2014

Statins with pomegranate juice may increase the risk of rhabdomyolysis

This study was published in the American Journal of Cardiology 2006 Sep 1;98(5):705-6

Study title and authors:
Rhabdomyolysis associated with pomegranate juice consumption.
Sorokin AV, Duncan B, Panetta R, Thompson PD.
Section of Preventive Cardiology, Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut, USA.

This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/16923466

This paper reports the case of a man who developed rhabdomyolysis after drinking pomegranate juice while taking statins.

(i) A 48-year-old man had been taking ezetimibe and rosuvastatin for 17 months.
(ii) Three weeks before admission to hospital, he began drinking pomegranate juice (200 ml twice weekly).
(iii) On admission he had thigh pain and elevated serum creatine kinase level (138,030 U/L, normal is less than 200 U/L) and was diagnosed with rhabdomyolysis.

Sorokin concludes: "This report suggests that pomegranate juice may increase the risk of rhabdomyolysis during rosuvastatin treatment".

Saturday, 26 July 2014

Statin use is associated with an increased risk of type two diabetes, which increases with longer duration of use

This study was published in BMC Cardiovascular Disorders 2014 Jul 15;14(1):85
 
Study title and authors:
Statins and the risk of type 2 diabetes mellitus: cohort study using the UK clinical practice pesearch datalink.
Macedo AF, Douglas I, Smeeth L, Forbes H, Ebrahim S.
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/25022519

This study aimed to assess the effect of statins on type two diabetes development. The study comprised of 2,016,094 individuals, including 430,890 people who received a statin, matched to 1,585,204 people not prescribed a statin.

The study found:
(a) Statin users had a 57% increased risk of developing diabetes compared to non-users.
(b) The risk of developing diabetes increased with longer duration of statin use:
(b1) Those who were followed for one to three years had a 22% increased risk of diabetes.
(b2) Those who were followed for 15 to 20 years had a 263% increased risk of diabetes.

Macedo concluded: "Statin use is associated with an increased risk of T2DM (type two diabetes), which increases with longer duration of use".

Sunday, 20 July 2014

Low cholesterol is associated with acute liver failure

This study was published in PLoS One 2014 Jul 15;9(7):e102351
 
Study title and authors:
Low levels of blood lipids are associated with etiology and lethal outcome in acute liver failure.
Manka P, Olliges V, Bechmann LP, Schlattjan M, Jochum C, Treckmann JW, Saner FH, Gerken G, Syn WK, Canbay A.
Department of Gastroenterology and Hepatology, University Hospital, University Duisburg-Essen, Essen, Germany
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/25025159

This study investigated the association between cholesterol levels with acute liver failure. The study included 89 acute liver failure patients.

The study found:
(a) The acute liver failure patients had low cholesterol, 121 mg/dL (3.1 mmol/L).
(b) The acute liver failure patients had low levels of low density lipoprotein (LDL) cholesterol, 63 mg/dL (1.6 mmol/L). 
(c) The acute liver failure patients had low levels of high density lipoprotein (HDL) cholesterol, 16 mg/dL (0.4 mmol/L).
(d) Cholesterol levels were a significant 41% lower in patients who died or required a liver transplant compared to patients who spontaneously recovered.
(e) LDL cholesterol levels were a significant 45% lower in patients who died or required a liver transplant compared to patients who spontaneously recovered.
(f) HDL cholesterol levels were a significant 61% lower in patients who died or required a liver transplant compared to patients who spontaneously recovered.
(g) Triglyceride levels were a significant 13% lower in patients who died or required a liver transplant compared to patients who spontaneously recovered.

The study reveals that low cholesterol is associated with acute liver failure.