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Showing posts with label Cholesterol and Motor Neuron Disease. Show all posts
Showing posts with label Cholesterol and Motor Neuron Disease. Show all posts

Monday, 19 April 2010

Statin drugs might be harmful for amyotrophic lateral sclerosis patients

This post contains a summary of a study published in Neurology Today 17 April 2008 - Volume 8 - Issue 8 - pp 1,9 and a recipe for quick chicken.

Study title and author:
High Cholesterol Levels May Benefit ALS Patients, Study Suggests
Samson, Kurt


In the American Academy of Neurology publication Neurology Today Kurt Samson reviews a study that investigates the association of cholesterol levels with survival rates in patients with amyotrophic lateral sclerosis. The study included 369 amyotrophic lateral sclerosis patients and 286 healthy individuals.

Samson's review found:
(a) Amyotrophic lateral patients with considerably higher cholesterol ratios lived, on average, one year longer than patients with lower levels.

Ignore the Awkward.: How the Cholesterol Myths Are Kept Alive
Books:
(b) Higher cholesterol levels may help prolong survival in patients with amyotrophic lateral sclerosis by warding off malnutrition and muscle wasting.
(c) The finding that high cholesterol is a prognostic factor for survival in amyotrophic lateral sclerosis patients, is of great significance, and calls into question the use of cholesterol-lowering medications (statins) in these patients.
(d) Statin therapy might increase the risk of amyotrophic lateral sclerosis or an amyotrophic lateral sclerosis-like syndrome.
(e) Raising the cholesterol levels of amyotrophic lateral sclerosis patients by dietary means might be beneficial.
(f) Doctors have noted the possible worsening effect of statins in amyotrophic lateral sclerosis patients and systematically stop statin drugs in patients.
(g) By reducing low density lipoprotein (LDL) cholesterol, statins decrease nutrient availability to muscle, which might contribute to neuromuscular junction damage and motor neuron death.
(h) Multiple pathways activated by statins might be deleterious in amyotrophic lateral sclerosis patients.

Hiroshi Mitsumoto, MD, the Wesley J. Howe Professor of Neurology at Columbia University and medical director of the Eleanor and Lou Gehrig MDA/ALS Center at Columbia Presbyterian Medical Center in New York City commented: "Many patients are taking statin drugs, and other experts have said the drugs might be harmful for amyotrophic lateral sclerosis patients, so we need to look into this immediately" and "it seems to me that amyotrophic lateral sclerosis patients benefit more from having higher blood fat levels".

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Quick Chicken

Ingredients:
2 large chicken breasts
5# Organic Chicken Breast
Food Mall: Chicken Breasts
2 cloves garlic minced
salt and pepper
2 tbs olive oil
1 cup stewed okra and tomatoes

Directions:
1. Cut chicken breasts into thirds on a diagonal.

2. Heat olive oil in a skillet on medium high heat. Wait til the pan is smoking a little.

3. Season chicken with salt and pepper.

4. Sear chicken for 3 minutes per side to brown it. Add minced garlic to pan and tomatoes and okra.

5. Cover pan and reduce heat to low. Cook for 10 minutes.