The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Wednesday, 21 April 2010

Decrease of Coenzyme Q10 during treatment with statins

This post includes a summary of a paper published in Molecular Aspects of Medicine 1997;18 Suppl:S137-44
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Study title and authors:
Dose-related decrease of serum coenzyme Q10 during treatment with HMG-CoA reductase inhibitors.
Mortensen SA, Leth A, Agner E, Rohde M.
Department of Medicine B, National University Hospital, Rigshospitalet, Copenhagen, Denmark.

This paper can be accessed at:

Mortensen notes that coenzyme Q10 (ubiquinone) is an antioxidant, a molecule that is essential in the chemical reactions of the mitochondria (for energy production) and may help to prevent clogged arteries.

This randomised in a double-blind trial investigated the effect of statin drugs on coenzyme Q10 levels. The trial included 45 patients with "high" cholesterol who were treated with increasing dosages of either lovastatin (20-80 mg per day) or pravastatin (10-40 mg per day) over a period of 18 weeks.

The study found after 18 weeks of statin therapy:
(a) The coenzyme Q10 levels of patients taking lovastatin decreased by 29%.
(b) The coenzyme Q10 levels of patients taking pravastatin decreased by 20%.

Mortensen concludes that: "continued vigilance of a possible adverse consequence from coenzyme Q10 lowering seems important during long-term (statin) therapy".

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