Study title and authors:
Value of HDL cholesterol, apolipoprotein A-I, lipoprotein A-I, and lipoprotein A-I/A-II in prediction of coronary heart disease: the PRIME Study. Prospective Epidemiological Study of Myocardial Infarction.
Luc G, Bard JM, Ferrières J, Evans A, Amouyel P, Arveiler D, Fruchart JC, Ducimetière P.
Department of Atherosclerosis, INSERM UR545, Institut Pasteur de Lille, and University Lille II, Lille, France. Gerald.Luc@pasteur-lille.fr
The paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/12117731
The study examined the association between the incidence of coronary heart disease and levels of high density lipoprotein (HDL) cholesterol, apolipoprotein A-I (apoA-I), and 2 HDL fractions, lipoprotein A-I and lipoprotein A-I:A-II in 9,073 French and Northern Irish men over a 5 year period.
The study found:
(a) All 4 HDL cholesterol parameter levels were lower in coronary heart disease patients than in coronary heart disease-free subjects.
(b) Low levels of apolipoprotein A-I (apoA-I) were a particularly strong predictor of heart disease.
The paper illustrates how low levels of HDL cholesterol
and especially low levels of apolipoprotein A-I (apoA-I) are a strong predictor of heart disease.The most effective dietary way to raise HDL cholesterol is to consume a diet rich in saturated fat. See here, here, here and here.
