Soy isoflavone and reproduction abnormalities

This post includes a synopsis of a study published in the The Journal of Urology Volume 169, Issue 4, April 2003, Pages 1582-1586 and a recipe for rolled lamb with garlic.

Study title and authors:
Exposure to Genistein During Gestation and Lactation Demasculinizes the Reproductive System in Rats
AMY B. WISNIEWSKI*, a, SABRA L. KLEINa, YEGAPPAN LAKSHMANANa and JOHN P. GEARHARTa
aFrom the Division of Pediatric Endocrinology, Department of Pediatrics and Division of Pediatric Urology, Department of Urology, James Buchanan Brady Urological Institute, The Johns Hopkins School of Medicine and W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.

This paper can be accessed at: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B7XMT-4HGCK42-3G&_user=10&_coverDate=04%2F30%2F2003&_rdoc=102&_fmt=high&_orig=browse&_origin=browse&_zone=rslt_list_item&_srch=doc-info(%23toc%2329679%232003%23998309995%23609761%23FLA%23display%23Volume)&_cdi=29679&_sort=d&_docanchor=&view=c&_ct=110&_acct=C000050221&_version=1&_urlVersion=0&_userid=10&md5=2321788edacdd37ed11eee1cdcee5bc7&searchtype=a
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Genistein is one of the main isoflavones found in soy. The results of the study found males exposed to genistein had smaller testis size, and long-term dysfunction in reproductive behavior, in which adult males exposed to genistein were less likely to mount, enter and ejaculate during mating tests. Males exposed to genistein also had lower testosterone concentrations in adulthood.

The study concluded "These results extend our knowledge of the effects of early genistein exposure on male development and may have implications for human health in terms of potential relationships of endocrine disrupters and urogenital abnormalities thought to be increasing in incidence in boys and men".

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Recipe of the day

Rolled Lamb with Garlic

Ingredients:

16 garlic cloves, unpeeled                                                                               Food Mall: Leg of Lamb

2 Tbsp chopped fresh parsley

2 tsp fresh oregano or 3/4 tsp dried
1 leg of lamb, boned, 3 1/2 to 4 pounds
3/4 tsp pepper
1 1/2 Tbsp olive oil

Instructions:
Preheat oven to 350F. Bake unpeeled garlic in a small baking pan covered with foil for 15 minutes. Peel garlic. Increase oven temperature to 475F.

Set lamb on work surface, boned side up. Scatter whole garlic cloves, parsley, and oregano over lamb. Season with 1/4 tsp pepper. Roll up roast and tie at 2-inch intervals. Rub lamb with olive oil. Season with remaining pepper.

Place lamb in an open roasting pan. Roast lamb at 475 for 15 minutes. Reduce oven temperature to 350 F. and cook 1hour 15 minutes longer, or until lamb is medium-rare.

Serve with pan juices.