The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 20 April 2010

Statins damage skeletal muscle

This post includes a summary of a paper published in the Journal of Pathology 2006 Sep;210(1):94-102 

Study title and authors:
Statin therapy induces ultrastructural damage in skeletal muscle in patients without myalgia.
Draeger A, Monastyrskaya K, Mohaupt M, Hoppeler H, Savolainen H, Allemann C, Babiychuk EB.
Institute of Anatomy, Department of Cell Biology, University of Bern, Baltzerstrasse 2, 3012 Bern, Switzerland.

This paper can be accessed at:

The Statin Damage Crisis
Draeger notes that muscle pain and weakness are frequent complaints in patients receiving statins. Many patients with muscle pain have creatine kinase levels that are either normal or only marginally elevated, and no obvious structural defects have been reported in patients with muscle pain.

In this study, skeletal muscle biopsies from statin-treated and non-statin-treated patients were examined using both electron microscopy and biochemical approaches to compare patterns of muscle damage.

The study found:
(a) The biopsies found clear evidence of skeletal muscle damage in statin-treated patients.
(b) The damage has a characteristic pattern that includes breakdown of the T-tubular system (continuation of the cell surface membrane) and subsarcolemmal (cell membrane) rupture.
(c) These characteristic structural abnormalities observed in the statin-treated patients were reproduced by extraction of cholesterol from skeletal muscle fibres and analysed in a test tube.

The researchers conclude: "These findings support the hypothesis that statin-induced cholesterol lowering per se contributes to myocyte (muscle cell or muscle fibre) damage".
More information on this subject: Books : Scientific Studies : Other Websites : Videos : Food Mall