The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 27 July 2010

Adverse Effects of Statins

This post features a summary of a study published in the International Journal of Pharmacology 1 (3): 210-225, 2005

Study title and authors:
Adverse Effects of Statins
Anna Jamroz-Wisniewska and Jerzy Bettowski
This study can be accessed at:

Dr Anna Jamroz-Wisniewska reviewed the evidence concerning the adverse effects of statins.

The review found:
(i) Statins inhibit the production of 3-hydroxy-3-methylglutarylcoenzyme A (HMG-CoA) reductase, an enzyme in cholesterol biosynthesis pathway, which initially converts HMG-CoA to mevalonate. Mevalonate is the precursor to cholesterol.
(ii) Apart from cholesterol, mevalonate is also a precursor for nonsteroid isoprenoids including farnesylpyrophosphate, geranylgeranylpyrophosphate, coenzyme Q, dolichol and isopentenylpyrophosphate which play an essential role in cellular physiology. 
(iii) The authors report that myopathy (muscle disease) is the most frequent side effect of statins. Other's include peripheral neuropathy (damage to nerves of the peripheral nervous system), hepatotoxicity (liver damage), increased risk of cataract and, according to some studies, increased risk of breast cancer.
(iv) Some studies suggest that statins may sometimes even be the cause of clogged arteries and heart failure.