The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Wednesday, 7 July 2010

Low cholesterol and suicidal behavior

Published in the Am J Psychiatry 161:2123-2126, November 2004

Cholesterol Metabolism and Suicidality in Smith-Lemli-Opitz Syndrome Carriers
Aleksandra Lalovic, M.Sc., Louise Merkens, Ph.D., Laura Russell, M.D., Geneviève Arsenault-Lapierre, B.Sc., Malgorzata J.M. Nowaczyk, M.D., Forbes D. Porter, M.D., Ph.D., Robert D. Steiner, M.D., and Gustavo Turecki, M.D., Ph.D.

This paper can be accessed at:
Smith-Lemli-Opitz syndrome (SLOS) is a multiple congenital anomalies (MCA)/mental retardation (MR) syndrome caused by a defect in cholesterol synthesis whereby affected individuals have low cholesterol levels. Severely affected individuals have multiple congenital malformations and are often miscarried or stillborn or die in the first weeks of life. Dysmorphic facial features, microcephaly, second-toe and third-toe syndactyly, other malformations, and MR are typical. Mildly affected individuals may have only subtle dysmorphic features and learning and behavioral disabilities.
The study found that more suicide attempts were reported among Smith-Lemli-Opitz syndrome carriers than among the comparison subjects.
The study provided additional evidence supporting the relationship between low cholesterol and suicidal behavior.
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