The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Saturday, 12 February 2011

Cholesterol deficiency may lead to the development of Alzheimer's

This post contains a summary of a paper published in the European Journal of Internal Medicine 22 (2011) 134-140

Study title and authors:
Nutrition and Alzheimer's disease: The detrimental role of a high carbohydrate diet
Stephanie Seneff , Glyn Wainwright , Luca Mascitelli ,
Department of Electrical Engineering and Computer Science, MIT Cambridge, MA, USA

This paper can be accessed at:

In this paper, the authors highlight how an excess of dietary carbohydrates, particularly fructose, alongside a relative deficiency in dietary fats and cholesterol, may lead to the development of Alzheimer's disease.

The lead author of the study, Dr Stephanie Seneff, explains
(a) The first step in Alheimer's is represented by advanced glycation end-products in crucial plasma proteins concerned with fat, cholesterol, and oxygen transport.
(b) This leads to cholesterol deficiency in neurons, which significantly impairs their ability to function.
(c) Over time this may lead to increased oxidative damage, mitochondrial and lysosomal dysfunction, increased risk to microbial infection, and, ultimately, cell death.

Dr Seneff concluded: "Other neurodegenerative diseases share many properties with Alzheimer's disease, and may also be due in large part to this same underlying cause".