The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Wednesday, 16 February 2011

Low cholesterol: a major risk factor for tuberculosis?

Published in Med Hypotheses. 2006;66(6):1227-30. Epub 2006 Feb 24.

Hypocholesterolemia: a major risk factor for developing pulmonary tuberculosis?
Pérez-Guzmán C, Vargas MH.
Instituto Nacional de Enfermedades Respiratorias, México DF, Mexico.

This paper can be accessed at:

Low cholesterol may be a major risk factor for tuberculosis because:
(a) cholesterol is an important molecule for the good functioning of an immune system, and is necessary for macrophages to uptake and engulf mycobacteria.
(b) tuberculous patients often have low cholesterol, in comparison with the general population and household contacts.
(c) cholesterol has a beneficial effect against pulmonary tuberculosis, since a cholesterol-rich diet accelerates the bacteriological sterilization of sputum.
(d) many conditions traditionally considered major risk factors for tuberculosis are accompanied by low cholesterol.

Pérez-Guzmán notes that cholesterol might be given to people with low cholesterol who are at high risk for developing pulmonary tuberculosis.

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