Dietary restriction of saturated fat and cholesterol decreases HDL ApoA-I secretion.
Vélez-Carrasco W, Lichtenstein AH, Welty FK, Li Z, Lamon-Fava S, Dolnikowski GG, Schaefer EJ.
Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts, USA.
This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10195918
As a major component of the high-density lipoprotein complex (HDL"good cholesterol"), ApoA-I helps to clear cholesterol from arteries and gives protection from heart disease.
The study examined the mechanisms responsible for the decrease in HDL cholesterol levels after the consumption of a diet low in total fat, saturated fat, and cholesterol. Twenty-one subjects with aa average age of 58 years were placed on:
Diet (1) Higher fat (15% protein, 49% carbohydrate, 36% fat, and 150 mg/1000 kcals of cholesterol)
and then switched to:
Diet (2) An National Cholesterol Education Program (NCEP) Step 2 diet lower fat (15% protein, 60% carbohydrate, 25% fat, and 45 mg/1000 kcals of cholesterol).
The study found that compared with the high fat diet, consumption of the lower fat diet lowered beneficial HDL and apoA-I cholesterol
levels by 15% and 12% respectively. AMAZON UK Put Your Heart in Your Mouth
AMAZON USA Put Your Heart in Your Mouth
