Circulating Endothelial Microparticles Are Associated with Vascular Dysfunction in Patients with End-Stage Renal Failure
Nicolas Amabile*, Alain P. Guérin†, Aurélie Leroyer*, Ziad Mallat*, Clément Nguyen*, Jacques Boddaert*, Gérard M. London†, Alain Tedgui* and Chantal M. Boulanger*
* Institut National de la Santé et de la Recherche Médicale, Cardiovascular Research Center INSERM Lariboisière, Unit 689, Paris; and † Nephrology Department Centre Hospitalier Manhes, Fleury Mérogis, France
This paper can be accessed at: http://jasn.asnjournals.org/content/16/11/3381.abstract
Amabile notes that endothelial dysfunction (narrowing of the blood vessels and reduced blood flow) is a major risk factor for heart disease in patients with end-stage renal failure (ESRF).
The study investigated the relationship between circulating microparticles and arterial dysfunction in patients with ESRF.
The results of study suggests that high levels of circulating endothelial microparticles are associated with endothelial dysfunction and arterial dysfunction in ESRF.
Elevated levels of endothelial microparticles are caused by diets high in vegetable oils
. See here.Blood flow can be improved by meals high in saturated fat, see here and diets low in carbohydrate, see here.
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Recipe of the day
Shepherd's Pie
Ingredients:
1 1/2 -2 pounds ground beef
Medium onion, chopped
14.5 oz. beef broth
3-4 bay leaves
1/2 t. pepper
1/4 t. dried thyme
About 8 sweet potatoes, peeled and cubed
1/2 c. (or more as needed) milk or cream
4 T. butter
1 T. minced chives
1 t. sea salt, divided
1 c. shredded cheese
About 2 cups frozen or fresh mixed veggies
Instructions:
In large skillet cook ground beef with onion, drain if needed. Stir in 1 c. broth, bay leaves, pepper, and thyme. Bring to a boil, reduce heat, cover and simmer for 30 min.
Meanwhile, boil potatoes, drain, mash with milk, butter, chives/garlic, and 1/2 t. salt. Stir in cheese, keep warm.
Add veggies and remaining salt to beef mixture. Cover and simmer for 10 minutes.
Bring beef mixture to boil, cook and stir for 1-2 minutes or ’til thick. Remove from heat, discard bay leaves.
Transfer beef mixture to greased 9×13 baking dish. Top with mashed potatoes. Sprinkle cheese over top if you didn’t add them to the potatoes.
Bake uncovered at 375 for 10 minutes or until heated.
