Study title and authors:
Simvastatin interferes with process outgrowth and branching of oligodendrocytes.
Smolders I, Smets I, Maier O, vandeVen M, Steels P, Ameloot M.
Biomedical Research Institute, School of Life Sciences, Hasselt University and Transnational University Limburg, Diepenbeek, Belgium.
This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20857509
The study focused on the effects of stain drugs on oligodendrocytes and myelin in a laboratory setting.
The study found:
(a) Cholesterol is required for the growth of oligodendrocytes.
(b) Statins inhibited the growth of oligodendrocytes.
(c) Statins inhibited the growth of myelin.
To conclude: Statin treatment has detrimental effects on oligodendrocyte growth, which is the prior step in (re)myelination, and thereby inhibits the healing of multiple sclerosis lesions.
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