This paper was published in the American Journal of Gastroenterology 1999 May;94(5):1388-90
Study title and authors:
Acute cholestatic hepatitis associated with pravastatin.
Study title and authors:
Acute cholestatic hepatitis associated with pravastatin.
Hartleb M, Rymarczyk G, Januszewski K.
Department of Gastroenterology, Silesian Medical School, Katowice, Poland.
This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10235223
Department of Gastroenterology, Silesian Medical School, Katowice, Poland.
This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10235223
This paper describes a 57 year old man with acute cholestatic hepatitis. (Acute cholestatic hepatitis is where the bile ducts of the liver become obstructed by inflammation and may lead to jaundice).
The report found:
The man's symptoms had appeared 7 weeks after he was started on pravastatin 20 mg/day for "high cholesterol".
Investigations revealed a diagnosis of intrahepatic nonobstructive jaundice.
The liver function abnormalities normalized 7 weeks after cessation of therapy.
This paper shows that statins should be considered as a potential cause of cholestatic hepatitis.
