The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Monday, 17 September 2012

Statins are a potential cause of cholestatic hepatitis

This paper was published in the American Journal of Gastroenterology 1999 May;94(5):1388-90

Study title and authors:
Acute cholestatic hepatitis associated with pravastatin.
Hartleb M, Rymarczyk G, Januszewski K.
Department of Gastroenterology, Silesian Medical School, Katowice, Poland.

This paper can be accessed at:

This paper describes a 57 year old man with acute cholestatic hepatitis. (Acute cholestatic hepatitis is where the bile ducts of the liver become obstructed by inflammation and may lead to jaundice).

The report found:
The man's symptoms had appeared 7 weeks after he was started on pravastatin 20 mg/day for "high cholesterol".

Investigations revealed a diagnosis of intrahepatic nonobstructive jaundice.

The liver function abnormalities normalized 7 weeks after cessation of therapy.

This paper shows that statins should be considered as a potential cause of cholestatic hepatitis.