The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Thursday, 31 January 2013

Statins exacerbate exercise-induced skeletal muscle injury

This study was published in Metabolism 1997 Oct;46(10):1206-10
Study title and authors:
Lovastatin increases exercise-induced skeletal muscle injury.
Thompson PD, Zmuda JM, Domalik LJ, Zimet RJ, Staggers J, Guyton JR.
Division of Cardiology, University of Pittsburgh, PA, USA.
This study can be accessed at:

This study investigated the association between statins, exercise and creatine kinase levels (high levels of creatine kinase are a marker for muscle damage) using a double-blind, placebo-controlled design. The study include 59 healthy men aged 18 to 65 years who were assigned to receive lovastatin (40 mg per day) or placebo for 5 weeks. The men completed 45 minutes of treadmill walking after 4 weeks of treatment.

The study found that the creatine kinase levels of the men who received lovastatin were 62% and 77% higher 24 and 48 hours after the treadmill exercise compared to the men who received placebo.

The researchers concluded that statins exacerbate exercise-induced skeletal muscle injury.