The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Sunday, 24 February 2013

Statins induce a decline in cognition

This paper was published in the Annals of Pharmacotherapy 2006 Oct;40(10):1880-3

Study title and authors:
Simvastatin-induced decline in cognition.
Padala KP, Padala PR, Potter JF.
Geriatrics Section, Department of Internal Medicine, 981320 Nebraska Medical Center, Omaha, NE 68198-1320, USA.

This paper can be accessed at:

This paper describes a case of new-onset cognitive difficulties in an older patient after initiation of simvastatin therapy.

(i) A 64-year-old man developed cognitive difficulties (short-term memory loss, long-term memory loss, and item misplacement) within one week after starting simvastatin 40 mg/day.
(ii) Simvastatin was discontinued, and the patient's cognition improved to normal within six weeks.
(iii) He again tried simvastatin, this time at half the original dose and his cognition deteriorated over a two week period.
(iv) Simvastatin was stopped, and his normal cognition returned within four weeks.

This case shows that statins can induce a decline in cognition.