The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 19 March 2013

Diets containing gluten cause gastrointestinal symptoms in non-celiacs

This study was published in the American Journal of Gastroenterology 2011 Mar;106(3):508-14; quiz 515

Study title and authors:
Gluten causes gastrointestinal symptoms in subjects without celiac disease: a double-blind randomized placebo-controlled trial.
Biesiekierski JR, Newnham ED, Irving PM, Barrett JS, Haines M, Doecke JD, Shepherd SJ, Muir JG, Gibson PR.
Monash University Department of Medicine and Gastroenterology, Box Hill Hospital, Box Hill, Victoria, Australia.

This study can be accessed at:

The aim of this study was to determine whether gluten ingestion can induce gastrointestinal symptoms in non-celiac individuals. A double-blind, randomized, placebo-controlled rechallenge trial was undertaken in patients with irritable bowel syndrome in whom celiac disease was excluded and who were symptomatically controlled on a gluten-free diet. The study included 34 patients (aged 29-59 years) who received either (i) gluten or (ii) placebo in the form of two bread slices plus one muffin per day with a gluten-free diet for up to 6 weeks.

The study found:
(a) 28% more of the patients in the gluten group reported that their symptoms were not adequately controlled compared to the placebo group.
(b) Patients in the gluten group were significantly worse within one week for the following:
(i) Overall symptoms.
(ii) Pain.
(iii) Bloating.
(iv) Less satisfaction with stool consistency.
(v) Tiredness.

The results from the study suggests that a diet containing gluten causes gastrointestinal symptoms in non-celiacs.