The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 26 March 2013

Statins can damage the lining of blood vessels

This study was published in Life Sciences 2013 Mar 18
Study title and authors:
Statin Therapy Influences Endothelial Cell Morphology and F-Actin Cytoskeleton Structure When Exposed to Static and Laminar Shear Stress Conditions.
Dick M, Jonak P, Leask RL.
Department of Chemical Engineering, McGill University, 3610 University Avenue, Montreal, Quebec, H3A 2B2, Canada.
This study can be accessed at:

The aim of the study was to determine how statin drugs affect endothelial cell shape and F-actin cytoskeleton arrangement. (Endothelial cells are the thin layer of cells that line the interior surface of blood vessels and lymphatic vessels, and F-actin cytoskeleton is part of the cells scaffolding or skeleton). In the study, human endothelial cells were cultured in the laboratory and were then treated with statins.

The study found:
(a) After been treated with statins the endothelial cells became rounded, which is associated with unhealthy cells in arteries prone to developing a build up of plaque.
(b) After been treated with statins the F-actin cytoskeleton structure was disorganized and fragmented which can lead to cell death.

The significance of the results of the study is that endothelial cells and F-actin cytoskeleton arrangement are advesely impacted by statin treatment which may increase the risk of arterial plaque and cell death.