The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Friday, 6 December 2013

Statins deplete levels of vitamin A, vitamin E and coenzyme Q10

This study was published in the Journal of the American Medical Association 2002 Feb 6;287
(5):598-605
 
Study title and authors:
Effects of diet and simvastatin on serum lipids, insulin, and antioxidants in hypercholesterolemic men: a randomized controlled trial.
Jula A, Marniemi J, Huupponen R, Virtanen A, Rastas M, Rönnemaa T.
Research and Development Centre of the Social Insurance Institution, Peltolantie 3, FIN-20720 Turku, Finland. antti.jula@kela.memonet.fi
 
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/11829698

This study investigated the effects of statins on men with cholesterol levels of at least 232 mg/dL (6.0 mmol/L). The study included 120 men, aged 35 to 64 years, who were randomly allocated to a habitual diet, or dietary treatment group, and each of these groups was further randomised to receive simvastatin or placebo, each for 12 weeks.

The study found:
(a) The alpha-tocopherol (vitamin E) levels of men taking simvastatin decreased by 16.2%.
(b) The beta-carotene (a precursor of vitamin A) levels of men taking simvastatin decreased by 19.5%.
(c) The ubiquinol-10 (ubiquinol-10 is the active form of coenzyme Q10) levels of men taking simvastatin decreased by 22%.
(d) The insulin levels of men taking simvastatin increased by 13.2%. (High insulin levels are associated with high blood pressure, heart disease, diabetes, weight gain, cancer and polycystic ovarian syndrome).