The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Monday, 12 January 2015

Statin use increases the risk of multiple colorectal adenomas by 25%

This study was published in Cancer Epidemiology, Biomarkers and Prevention 2005 Apr;14(4):1026-7

Study title and authors:
Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas.
Wei JT, Mott LA, Baron JA, Sandler RS; Polyp Prevention Study Group.
Division of Gastroenterology and Hepatology, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599, USA.

This study can be accessed at:

This study investigated the association of statins with the risk of recurrent colorectal adenomas. (An adenoma is a benign tumour. Colorectal adenomas are removed because of their tendency to become malignant and to lead to colon cancer). The study analysed data from three randomised trials regarding the recurrence of colorectal adenomas in patients with a history of adenomas. The trials included 2,638 patients.

The analysis revealed:
(a) Statin users had a 3% increased risk of any adenoma compared to statin never-users.
(b) Statin users had a 13% increased risk of any advanced adenoma compared to statin never-users.
(c) Statin users had a 25% increased risk of multiple adenoma compared to statin never-users.
Links to other studies: