This study was published in Cancer Epidemiology, Biomarkers and Prevention 2005 Apr;14(4):1026-7
Study title and authors:
Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas.
Study title and authors:
Reported use of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors was not associated with reduced recurrence of colorectal adenomas.
Wei JT, Mott LA, Baron JA, Sandler RS; Polyp Prevention Study Group.
Division of Gastroenterology and Hepatology, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599, USA. jwei@med.unc.edu
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15824186
Division of Gastroenterology and Hepatology, University of North Carolina, Campus Box 7080, Chapel Hill, NC 27599, USA. jwei@med.unc.edu
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15824186
This study investigated the association of statins with the risk of recurrent colorectal adenomas. (An adenoma is a benign tumour. Colorectal adenomas are removed because of their tendency to become malignant and to lead to colon cancer). The study analysed data from three randomised trials regarding the recurrence of colorectal adenomas in patients with a history of adenomas. The trials included 2,638 patients.
The analysis revealed:
(a) Statin users had a 3% increased risk of any adenoma compared to statin never-users.
(b) Statin users had a 13% increased risk of any advanced adenoma compared to statin never-users.
(c) Statin users had a 25% increased risk of multiple adenoma compared to statin never-users.
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