Statins significantly lower testosterone levels

This study was published in the European Journal of Endocrinology 2015 Aug;173(2):155-65

Study title and authors:
Use of statins is associated with lower serum total and non-sex hormone-binding globulin-bound testosterone levels in male participants of the Rotterdam Study.

de Keyser CE, de Lima FV, de Jong FH, Hofman A, de Rijke YB, Uitterlinden AG, Visser LE, Stricker BH.
Department of EpidemiologyErasmus Medical Center, PO Box 2040, 3000CA Rotterdam

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/26034077

Low testosterone is associated with an increase in heart disease and death rates, see here. Testosterone not bound to sex hormone-binding globulin (non-sex hormone-binding globulin-bound testosterone) is an indicator of biologically available Testosterone.

The objective of the study was to investigate the association between the use of statins and testosterone levels in men. The study included 4,166 men, average age 64 years.

The study found:
(a) Current users of statins had significantly lower total testosterone levels compared to non-users.
(b) Current users of statins had significantly lower non-sex hormone-binding globulin-bound testosterone levels compared to non-users.

de Keyser concluded: "We showed that current use of statins was associated with significantly lower serum total and non-sex hormone-binding globulin-bound testosterone levels."

Links to other studies:
Statins increase the risk of erectile dysfunction by 51%
Ladies: No need to feign a headache - just give your man a statin!
Statins unequivocally associated with lower levels of testosterone