High Glucose Causes Apoptosis in Cultured Human Pancreatic Islets of Langerhans
Massimo Federici1, Marta Hribal1, Lucia Perego210, Marco Ranalli3, Zaira Caradonna2, Carla Perego4, Luciana Usellini5, Rita Nano6, Paolo Bonini1, Federico Bertuzzi6, Lionel N.J.L. Marlier12, Alberto M. Davalli7, Orazio Carandente8, Antonio E. Pontiroli210, Gerry Melino3, Piero Marchetti9, Renato Lauro1, Giorgio Sesti11 and Franco Folli2
1Department of Internal Medicine, University of Rome “Tor Vergata,” Rome
2Unit for Metabolic Diseases, Scientific Institute for Research and Cure (IRCCS), Hospital San Raffaele, Milan
3IDI-IRCCS Biochemistry Lab c/o the Department of Experimental Medicine, University of Rome “Tor Vergata,” Rome
4National Research Center (CNR), Centro per lo Studio della Farmacologia Cellulare e Molecolare, Milano
5Department of Surgical Pathology, Università dell’Insubria, Varese; Departments of
6Surgery
7Medicine, and
8Cardiology, IRCCS HS Raffaele, Milan
9Department of Endocrinology and Metabolism, University of Pisa, Pisa
10Department of Internal Medicine, University of Milan, Milan
11Department of Clinical and Experimental Medicine, University of Catanzaro, Catanzaro
12Institute of Neurobiology and Molecular Medicine, CNR, Rome, Italy
The study can be accessed at: http://diabetes.diabetesjournals.org/content/50/6/1290.abstract
The data in the study suggests that in human islets, high glucose from a high carbohydrate diet may cause β-cell death, thus leading to diabetes.
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