The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 27 July 2010

Doctor's low awareness of statin side effects

This post includes a summary of a study published in the American Journal of Cardiovascular Drugs: 1 November 2008 - Volume 8 - Issue 6 - pp 373-418

Study title and authors:
Statin Adverse Effects: A Review of the Literature and Evidence for a Mitochondrial Mechanism
Golomb, Beatrice A; Evans, Marcella A
Statin Drugs Side Effects and the Misguided War on Cholesterol
Dr Beatrice Golomb reviewed the scientific literature regarding the adverse effects caused by statin drugs.

This paper can be accessed at:

Dr Golomb found:
(a) Muscle adverse events were the most reported problem both in the literature and by patients.
(b) In meta-analyses of randomized controlled trials, muscle adverse events are more frequent with statins than with placebo.
(c) A number of manifestations of muscle adverse eventss have been reported, with rhabdomyolysis the most feared.
(d) Adverse events are dose dependent, and risk is amplified by drug interactions that functionally increase statin potency.
(e) An array of additional risk factors for statin AEs are those that amplify (or reflect) mitochondrial or metabolic vulnerability, such as metabolic syndrome factors, thyroid disease, and genetic mutations linked to mitochondrial dysfunction.
(f) Converging evidence supports a mitochondrial foundation for muscle adverse events associated with statins, and both theoretical and empirical considerations suggest that mitochondrial dysfunction may also underlie many nonmuscle statin adverse events.
(g) Evidence from randomized controlled trials and studies of other designs indicates existence of additional statin-associated adverse events, such as cognitive loss, neuropathy, pancreatic and hepatic dysfunction, and sexual dysfunction.
(h) Physician awareness of statin advers events is reportedly low even for the adverse events most widely reported by patients.
(i) Awareness and vigilance for adverse events should be maintained to enable informed treatment decisions, treatment modification if appropriate, improved quality of patient care, and reduced patient morbidity.

The paper outlines the unhealthy adverse effects of statins and that doctors have a low awareness of the problems.
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