The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Friday, 10 September 2010

Statin exposure causes birth abnormalities

This post includes a synopsis of a paper published in the New England Journal of Medicine 350, 1579-82 2004

Study title and authors:
Central Nervous System and Limb Anomalies in Case Reports of First-Trimester Statin Exposure
Robin J. Edison, M.D., M.P.H. Maximilian Muenke, M.D.
National Institutes of Health Bethesda, MD 20892-1852
Malignant Medical Myths: Why MEdical Treatment Causes 200,000 Deaths in the USA each Year, and How to Protect Yourself

This paper can be accessed at:

The paper reviewed 52 cases of first-trimester statin exposure reported to the Food and Drug Administration (FDA).

The review found:
(a) Among these cases, there were 20 reports of malformation, including 5 severe defects of the central nervous system (2 of which were holoprosencephaly) and 5 unilateral limb deficiencies.
(b) One patient had both of these malformations. The two simvastatin-exposed cases of limb deficiency were complex lower-limb anomalies including both long-bone shortening and aplasia or hypoplasia of the foot structures. The infant in one of these cases and a lovastatin-exposed infant also had rare forms of the VACTERL association (i.e., three or more of the following findings: vertebral, anal, cardiac, tracheal, esophageal, renal, and limb defects).
(c) It is thought that only a small proportion of statin adverse events are reported to the FDA.
(d) There would be no expected cases of most of the malformations listed in the paper; yet three rare anomalies are each observed twice.

Dr Edison concludes that these findings support the need for controlled studies evaluating the potential birth defects effects of statin drugs.
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