High fat meals assist in the treatment of tuberculosis

This post includes a summary of a study published in Tuberculosis (Edinb) 2004;84(6):365-73 and a recipe for Italian veal chops.

Study title and authors:
Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.

Books:

Nix DE, Adam RD, Auclair B, Krueger TS, Godo PG, Peloquin CA.

University of Arizona College of Pharmacy, P.O. Box 210-207, Tucson, AZ 85721-0207, USA. nix@pharmacy.arizona.edu

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15525560

Clofazimine is an antibiotic and is potentially useful for the treatment of disease due to multidrug resistant Mycobacterium tuberculosis, as well as leprosy and certain chronic skin diseases. The study was conducted to explore issues relating to bioavailability in the presence of food, orange juice, and antacid.

The authors concluded administration of clofazimine with a high fat meal provides the greatest bioavailability. Both orange juice and aluminum-magnesium antacid produced a reduction in mean bioavailability of clofazimine.

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Recipe of the day

Italian Veal Chops

Food Mall: Veal Chops

Ingredients:

8 veal chops

pepper to taste
oregano
chopped parsley
2 garlic cloves, minced
1 can (1 lb. 12 oz) tomatoes

Instructions:
In skillet, brown chops. Season with pepper. Sprinkle with oregano and parsley. Add garlic and tomatoes. Cover and simmer until tender, about 2 hours.


Italian Veal Chops