Study title and authors:
Effects of four different meal types on the population pharmacokinetics of single-dose rifapentine in healthy male volunteers.
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20516273
Rifapentine is an antibiotic drug used in the treatment of tuberculosis.
The study measured the effect of four different meals on rifapentine oral bioavailability. The meals were:
high fat (meal A), (English breakfast)
bulk and low fat (meal B), (maize meal porridge)
bulk and high fat (meal C), (maize meal porridge with lard)
high fluid and low fat (meal D) (chicken noodle soup)
Compared with the fasting state meal A (English breakfast, which included bacon, fried eggs, butter and full-cream milk) had the greatest effect on rifapentine oral bioavailability, increasing it by 86%.
The lowest effect was in meal B (maize meal porridge) which only registered a 33% increase. However when lard was added to the maize meal porridge, bioavailability increased to 46%.
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Recipe of the day
Fried Eggs and Bacon with Sliced Grape Tomatoes
|Food Mall: Eggs|
15 grape tomatoes
Add bacon to cold skillet and set heat to low. Bacon does not curl when added to a cold skillet and cooks best over low heat. Turn bacon frequently and allow browning to desired level of crispiness, which for me takes 3-4 minutes. Remove bacon to a paper towel to soak up excess grease. Crack three eggs into the hot bacon grease in skillet. Salt and pepper to taste. Pierce yolks with a spatula to ensure even cooking. Add sliced tomatoes across eggs as they are cooking. Turn eggs with spatula to insure that all parts have cooked well. Transfer to plate and add bacon on the side.