This study was published in Internal Medicine 2010;49(13):1271-6
Study title and authors:
Diabetes progression from "high-normal" glucose in school teachers.
Moriuchi T, Oka R, Yagi K, Miyamoto S, Nomura H, Yamagishi M, Mabuchi H, Kobayashi J, Koizumi J.
Metabolic and Vascular Science, Division of Cardiovascular Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa.
High-normal glucose, is the intermediate category between normal fasting glucose and impaired fasting glucose. The aim of the study was to investigate the risk for future incidence of type 2 diabetes of the subjects with high-normal glucose. In the study 4,165 non-diabetic people were followed for 5 years.
They were classified with either:
(i) Normal fasting glucose (less than 100 mg/dL or 5.5 mmol/l)
(ii) High-normal fasting glucose (100-109 mg/dL or 5.6-6.0 mmol/l)
(iii) Impaired fasting glucose (110-125 mg/dL or 6.1-7.0 mmol/l)
After 5 years:
(a) 0.5% of those who had normal fasting glucose developed type 2 diabetes.
(b) 6.5% of those who had high-normal glucose developed type 2 diabetes.
(c) 28.2% of those who had impaired fasting glucose developed type 2 diabetes.
The study found the future incidence of type 2 diabetes in people with high-normal glucose was significantly higher than in those with normal fasting glucose.
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