The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Sunday, 13 February 2011

Statins put patients at risk from depression and chronic fatigue syndrome

This post includes a summary of a paper published in Neuroendocrinology Letters 2009;30(4):462-9
Malignant Medical Myths: Why MEdical Treatment Causes 200,000 Deaths in the USA each Year, and How to Protect Yourself

Study title and authors:
Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness.
Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.
Maes Clinics, Antwerp, Belgium.

This paper can be accessed at:

The researchers note how there is now evidence that major depression is accompanied by an induction of inflammatory and oxidative and nitrosative stress pathways and by a lowered antioxidant status. Coenzyme Q10 is a strong antioxidant that has anti-inflammatory effects.

This study examines the relationship between coenzyme Q10 levels, treatment resistant depression and chronic fatigue syndrome. The study included 35 depressed patients and 22 normal volunteers.

The study found:
(a) Coenzyme Q10 levels were significantly lower in depressed patients than in normal volunteers.
(b) Coenzyme Q10 levels were significantly lower in patients with treatment resistant depression and with chronic fatigue syndrome than in the other depressed patients.

The results show that lower coenzyme Q10 levels plays a role in depression and in particular in treatment resistant depression and with chronic fatigue accompanying depression.

The researchers note that the findings that lower coenzyme Q10 levels are a risk factor to coronary artery disease and chronic heart failure and mortality due to chronic heart failure suggest that low coenzyme Q10 levels are another factor explaining the risk to cardiovascular disorder in depression.

They conclude: "Since statins significantly lower plasma coenzyme Q10, depressed patients and in particular those with treatment resistant depression and with chronic fatigue syndrome represent populations at risk to statin treatment".

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