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Study title and authors:
Lower plasma Coenzyme Q10 in depression: a marker for treatment resistance and chronic fatigue in depression and a risk factor to cardiovascular disorder in that illness.
Maes M, Mihaylova I, Kubera M, Uytterhoeven M, Vrydags N, Bosmans E.
Maes Clinics, Antwerp, Belgium. crc.mh@telenet.beThis paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20010493
The researchers note how there is now evidence that major depression is accompanied by an induction of inflammatory and oxidative and nitrosative stress pathways and by a lowered antioxidant status. Coenzyme Q10 is a strong antioxidant that has anti-inflammatory effects.
This study examines the relationship between coenzyme Q10 levels, treatment resistant depression and chronic fatigue syndrome. The study included 35 depressed patients and 22 normal volunteers.
The study found:
(a) Coenzyme Q10 levels were significantly lower in depressed patients than in normal volunteers.
(b) Coenzyme Q10 levels were significantly lower in patients with treatment resistant depression and with chronic fatigue syndrome than in the other depressed patients.
The results show that lower coenzyme Q10 levels plays a role in depression and in particular in treatment resistant depression and with chronic fatigue accompanying depression.
The researchers note that the findings that lower coenzyme Q10 levels are a risk factor to coronary artery disease and chronic heart failure and mortality due to chronic heart failure suggest that low coenzyme Q10 levels are another factor explaining the risk to cardiovascular disorder in depression.
They conclude: "Since statins significantly lower plasma coenzyme Q10, depressed patients and in particular those with treatment resistant depression and with chronic fatigue syndrome represent populations at risk to statin treatment".
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