The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Thursday, 10 March 2011

Cancer's link to a lack of cholesterol

This paper was published in Nature Reviews. Molecular Cell Biology 2004 Jan;5(1):45-54

Study title and authors:
From polyploidy to aneuploidy, genome instability and cancer.
Storchova Z, Pellman D.
Department of Pediatric Oncology of The Dana-Farber Cancer Institute, Children's Hospital and Harvard Medical School, Room M621A, 44 Binney Street Boston, Massachusetts 02115, USA.

This paper can be accessed at:

Storchova notes that a growing amount of evidence indicates that polyploid cells arise during a variety of pathological conditions.

Aneuploidy is an abnormal number of chromosomes. Chromosome abnormalities occur in 1 of 160 live births, the most common that infants can survive with is an extra chromosome 21, which is found in Down syndrome.                  

Genetic instability in polyploid cells might lead to aneuploidy (which is associated with tumors) and thereby contribute to the development of cancer.

Polyploid cells may arise by a lack of cholesterol. See here.

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