Study title and authors:
From polyploidy to aneuploidy, genome instability and cancer.
Storchova Z, Pellman D.
Department of Pediatric Oncology of The Dana-Farber Cancer Institute, Children's Hospital and Harvard Medical School, Room M621A, 44 Binney Street Boston, Massachusetts 02115, USA.
This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/14708009
Storchova notes that a growing amount of evidence indicates that polyploid cells arise during a variety of pathological conditions.
Aneuploidy is an abnormal number of chromosomes. Chromosome abnormalities occur in 1 of 160 live births, the most common that infants can survive with is an extra chromosome 21, which is found in Down syndrome.
Genetic instability in polyploid cells might lead to aneuploidy (which is associated with tumors) and thereby contribute to the development of cancer.
Polyploid cells may arise by a lack of cholesterol.
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