The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Thursday, 10 March 2011

Cholesterol is essential for renewal of cells and wound healing

This study was published in Experimental Cell Research Volume 300, Issue 1, 15 October 2004, Pages 109-120

Study title and authors:
Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation
Carlos Fernández, María del Val T. Lobo, c, Diego Gómez-Coronado and Miguel A. Lasunción, d,
Servicio de Bioquímica-Investigación, Hospital Ramón y Cajal, Madrid, Spain

This paper can be accessed at:

Fernández notes that cholesterol is an essential component of cell membranes.

Mitosis is a process of cell division which results in the production of two daughter cells from a single parent cell. The daughter cells are identical to one another and to the original parent cell. Mitosis plays a role in cell replacement and wound healing. Cytokinesis is the final stage of mitosis where a single parent cell forms the two new cells.

The aim of the study was to determine the role of cholesterol in mitosis. For this human cells were incubated in a cholesterol free medium and the results observed were:

(a) Prolonged cholesterol starvation inhibitied cytokinesis and caused the formation of polyploid cells, which were multinucleated (cells which have more than one nucleus per cell and are implicated in tumour formation) and had other abnormalities.
(b) Supplementing with cholesterol completely abolished these adverse effects, demonstrating they were specifically due to cholesterol deficiency.

Polyploid cells are implicated in cancer, Alzheimer's disease and ataxia telangiectasia (Ataxia-telangiectasia is rare childhood disease that affects the brain and other parts of the body such as uncoordinated movements and retarded mental ability)

Fernández concluded: "Cholesterol is essential for mitosis completion and that, in the absence of cholesterol, the cells fail to undergo cytokinesis... generating polyploid cells".