The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 1 March 2011

High carbohydrate diets can increase uric acid levels which may lead to gout.

Published in Metabolism Volume 34, Issue 8, August 1985, Pages 741-746

Hyperuricemia and hypertriglyceridemia: Metabolic basis for the association
Irving H. Fox, a, b, David Johna, b, 1, Sandra DeBruynea, b, Issac Dwosha, b, 2 and Errol B. Marlissa, b, 3
aHuman Purine Research Center, Department of Internal Medicine, The University of Michigan USA
bDepartment of Biological Chemistry, The University of Michigan USA.

This paper can be accessed at:

Gout is a kind of arthritis that occurs when uric acid builds up in the joints, often in the big toe. Fox notes that high triglyceride levels have been reported frequently in patients with high uric acid levels and gout.

Fox examined whether high carbohydrate intake increases uric acid and triglyceride levels in people with gout and without gout.

The study found that:
(a) A pure carbohydrate (sucrose) diet increases both the uric acid and triglyceride levels.
(b) The mechanism of the excess uric acid in people with gout was increased uric acid production and less efficient and decreased uric acid clearance by the kidney
(c) The mechanism of the excess uric acid in people without gout is because the kidney becomes less efficient at clearing uric acid.

To summarise: The pure carbohydrate diet can increase uric acid levels which may lead to gout.

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