The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Friday, 30 April 2010

Statin drug induces rhabdomyolysis

This post includes a summary of a paper published in Clinical Therapeutics 2007 Jan;29(1):172-6

Statin Drugs Side Effects and the Misguided War on Cholesterol
Study title and authors:
Asymptomatic statin-induced rhabdomyolysis after long-term therapy with the hydrophilic drug pravastatin.
Schindler C, Thorns M, Matschke K, Tugtekin SM, Kirch W.
Institute of Clinical Pharmacology, Faculty of Medicine, Technical University of Dresden, Dresden, Germany.

This paper can be accessed at:

This paper discusses how a patient developed rhabdomyolysis after three years of statin treatment.

(i) A male patient aged 73 years presented to the emergency department with dyspnea (shortness of breath).
(ii) He had undergone heart transplantation seven years earlier and been receiving daily pravastatin therapy for more than three years without complaining of any symptoms.
(iii) Laboratory testing revealed that his creatine kinase levels was substantially above the reference range. (High creatine kinase levels indicate injury or stress to muscle tissue, the heart, or the brain).
(iv) Pravastatin was immediately discontinued, and the patient was admitted to the intensive care unit for treatment.
(v) Creatine kinase values declined after three days, and they returned to within reference range after three weeks.
(vi) The patient was diagnosed with acute rhabdomyolysis.

Schindler concludes: "The occurrence of acute statin-induced rhabdomyolysis in this case suggests that statins may have the potential to damage myocytes (muscle cells)".
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