This study was published in the British Medical Journal 2000 August 12; 321(7258): 405–412
Study title and authors:
Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study
Irene M Stratton, senior statistician,a Amanda I Adler, epidemiologist,a H Andrew W Neil, university lecturer in clinical epidemiology,b David R Matthews, consultant diabetologist,c Susan E Manley, biochemist,a Carole A Cull, senior statistician,a David Hadden, consultant physician,d Robert C Turner, director,e and Rury R Holman, directora on behalf of the UK Prospective Diabetes Study Group
aDiabetes Trials Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, Oxford OX2 6HE, bDivision of Public Health and Primary Care, Institute of Health Sciences, University of Oxford, Oxford OX3 7LF, cOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary, dRoyal Victoria Hospital, Belfast BT12 6BA, eDiabetes Research Laboratories, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Radcliffe Infirmary
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC27454/?tool=pmcentrez
The objective of this study was to determine the relationship between exposure to high blood sugar over time (HbA1-C levels) and the risk of health complications in patients with type 2 diabetes. In total, the HbA1-C levels of 3,642 patients were analysed.
The study found that for every 1% reduction in HbA1-C levels:
(a) There was a reduction of 21% in diabetes incidence.
(b) There was a reduction of 21% in deaths related to diabetes.
(c) There was a reduction of 14% in the total death rate.
(d) There was a reduction of 14% in fatal and non fatal heart attacks.
(e) There was a reduction of 12% in fatal and non fatal stroke.
(f) There was a reduction of 16% in heart failure.
(g) There was a reduction of 43% in amputations or death from peripheral vascular disease.
This study reveal that in patients with type 2 diabetes the risk of diabetic complications, such as heart disease, was strongly associated with high blood sugar (HbA1-c levels). Any reduction in blood sugar reduce the risk of complications.
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