The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Tuesday, 8 February 2011

The adverse effects of statins might be much more prevalent than widely considered

This post contains a summary of a paper published in Drug Safety 2002;25(12):877-83 and a recipe for braised shoulder of lamb.

Study title and authors:
Oxidation injury in patients receiving HMG-CoA reductase inhibitors: occurrence in patients without enzyme elevation or myopathy.
Statin Drugs Side Effects and the Misguided War on Cholesterol
Sinzinger H, Chehne F, Lupattelli G.
Wilhelm Auerswald Atherosclerosis Research Group (ASF), Vienna, Austria.

This paper can be accessed at:

The aim of this study was to investigate whether patients with heterozygous familial hypercholesterolaemia (high cholesterol) who did not exhibit any apparent side-effects during six months of treatment with statins drugs did in fact exhibit oxidation injury (cellular and tissue damage) as measured by isoprostane levels. (Elevated isoprostane levels are a marker for oxidation injury). The study included 111 patients (63 males, 48 females; aged 19 to 58 years) who did not experience any adverse effects during statin treatment.

The study found that out of the 111 treated patients (who did not experience any apparent adverse effects during statin treatment) 11 showed a pronounced increase in isoprostane levels.

The lead investigator of the study, Dr Helmut Sinzinger from the Wilhelm Auerswald Atherosclerosis Research Group Vienna, concluded: "These findings indicate that in the absence of other clinically observable adverse effects, in some of the patients, for an as yet unknown reason, statin therapy may be associated with increased oxidation injury. These data add a further piece of evidence that mild adverse effects of statins that are difficult to assess might be much more prevalent than widely considered".

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