Study title and authors:
Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.
Rundek T, Naini A, Sacco R, Coates K, DiMauro S.
Department of Neurology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.
This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15210526
The study found:
(a) Coenzyme Q(10) levels dropped by 51% after 30 days of statin thearpy.
(b) A significant decrease was already detectable after 14 days of treatment.
To conclude: Even brief exposure to statins causes a marked decrease in blood CoQ(10) concentration. Widespread inhibition of CoQ(10) synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, muscle pain, and rhabdomyolysis.
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