The raison d'etre of this website is to provide you with hard scientific information which may help you make informed decisions in your quest for health (so far I have blogged concise summaries of over 1,500 scientific studies and have had three books published).

My research is mainly focused on the effects of cholesterol, saturated fat and statin drugs on health. If you know anyone who is worried about their cholesterol levels and heart disease, or has been told to take statin drugs you could send them a link to this website, and to my statin or cholesterol or heart disease books.

David Evans

Independent Health Researcher

Saturday, 11 June 2011

Even brief exposure to statins causes muscle damage

This post includes a synopsis of a study published in the Archives of Neurology 2004 Jun;61(6):889-92

Study title and authors:
Atorvastatin decreases the coenzyme Q10 level in the blood of patients at risk for cardiovascular disease and stroke.
Rundek T, Naini A, Sacco R, Coates K, DiMauro S.
Department of Neurology, Columbia University College of Physicians & Surgeons, New York, NY 10032, USA.

This study can be accessed at:

Clean: The Revolutionary Program to Restore the Body's Natural Ability to Heal Itself
Rundek notes there have been various adverse effects of statin drugs, including problems commonly affecting muscle and ranging from muscle pain to the rapid destruction of skeletal muscle which can then cause kidney failure (rhabdomyolysis). These adverse effects may be due to a coenzyme Q(10) (CoQ(10)) deficiency because inhibition of cholesterol biosynthesis also inhibits the synthesis of CoQ(10).

The objective of the study was to measure CoQ(10) levels in blood from subjects with high cholesterol levels before and after exposure to atorvastatin at 14 and 30 days.
The study found:
(a) Coenzyme Q(10) levels dropped by 51% after 30 days of statin thearpy.
(b) A significant decrease was already detectable after 14 days of treatment.
To conclude: Even brief exposure to statins causes a marked decrease in blood CoQ(10) concentration. Widespread inhibition of CoQ(10) synthesis could explain the most commonly reported adverse effects of statins, especially exercise intolerance, muscle pain, and rhabdomyolysis.

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