NSAIDs and statins increase the risk of renal cell carcinoma

This study was presented at the American Urological Association Annual Meeting; May 19-23, 2012; Atlanta, GA. Abstract 575.

Study title and authors:
NSAID and statin use and risk of renal cell carcinoma.
Chéry L, Wright J, Hotaling J,

This study can be accessed at: http://www.onclive.com/publications/urologists-in-cancer-care/2012/June-2012/NSAIDs-and-Statins-Have-No-Impact-on-Renal-Cell-Carcinoma-Risk

Nonsteroidal anti-inflammatory drugs, or NSAIDs are the most prescribed medications for treating conditions such as arthritis. Examples of NSAIDs are aspirin, ibuprofen, naproxen and Nabumetone.

Chery notes that renal cell carcinoma, the most common type of kidney cancer, is the sixth most common cancer in men and the eighth most common cancer in women.

This study set out to determine the effect of NSAIDs and statins on the risk of renal cell carcinoma.  The study included 77,048 individuals aged 50 to 76 years

The study found:
(a) Those with a low use of NSAIDs (1-3 days/week or less than four years) had a 1% increased risk of developing renal cell carcinoma compared to nonusers of NSAIDs.
(b) Those with a high use of NSAIDs (more than four days/week and over four years) had a 20% increased risk of developing renal cell carcinoma compared to nonusers of NSAIDs.
(c) Those who were taking statins had a 10% increased risk of developing renal cell carcinoma.

The data from the study reveals that NSAIDs and statins increase the risk of renal cell carcinoma.

Ibuprofen increases the risk of breast cancer by 51%

This study was published in the Journal of the National Cancer Institute 2005 Jun 1;97(11):805-12

Study title and authors:

Nonsteroidal anti-inflammatory drug use and breast cancer risk by stage and hormone receptor status.

Marshall SF, Bernstein L, Anton-Culver H, Deapen D, Horn-Ross PL, Mohrenweiser H, Peel D, Pinder R, Purdie DM, Reynolds P, Stram D, West D, Wright WE, Ziogas A, Ross RK.

Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA. smarshal@usc.edu

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15928301

The study analyzed data on 114,460 women aged 22 to 85 years to investigate the relationship between breast cancer and aspirin and ibuprofen use.

The study found:

• Women who used aspirin between 1 and 6 days a week had a 9% increase in breast cancer rates compared to women who rarely used aspirin.
• Women who used aspirin between 1 and 6 days a week in a period of over 5 years had a 12% increase in breast cancer rates compared to women who rarely used aspirin.
• Women who took ibuprofen daily had a 24% increase in breast cancer rates compared to women who rarely used ibuprofen.
• Women who took ibuprofen daily in a period of over 5 years had a 51% increase in breast cancer rates compared to women who rarely used ibuprofen.

This study shows that aspirin and ibuprofen use increase the incidence of breast cancer.