High fat meals assist in the treatment of tuberculosis

This post includes a summary of a study published in Tuberculosis (Edinb) 2004;84(6):365-73 and a recipe for Italian veal chops.

Study title and authors:
Pharmacokinetics and relative bioavailability of clofazimine in relation to food, orange juice and antacid.

Books:

Nix DE, Adam RD, Auclair B, Krueger TS, Godo PG, Peloquin CA.

University of Arizona College of Pharmacy, P.O. Box 210-207, Tucson, AZ 85721-0207, USA. nix@pharmacy.arizona.edu

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/15525560

Clofazimine is an antibiotic and is potentially useful for the treatment of disease due to multidrug resistant Mycobacterium tuberculosis, as well as leprosy and certain chronic skin diseases. The study was conducted to explore issues relating to bioavailability in the presence of food, orange juice, and antacid.

The authors concluded administration of clofazimine with a high fat meal provides the greatest bioavailability. Both orange juice and aluminum-magnesium antacid produced a reduction in mean bioavailability of clofazimine.

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Recipe of the day

Italian Veal Chops

Food Mall: Veal Chops

Ingredients:

8 veal chops

pepper to taste
oregano
chopped parsley
2 garlic cloves, minced
1 can (1 lb. 12 oz) tomatoes

Instructions:
In skillet, brown chops. Season with pepper. Sprinkle with oregano and parsley. Add garlic and tomatoes. Cover and simmer until tender, about 2 hours.


Italian Veal Chops



High fat diets help to treat tuberculosis

This post includes a synopsis of a study published in Antimicrobial Agents and Chemotherapy  2010 Aug;54(8):3390-4 and a recipe for fried eggs and bacon with sliced grape tomatoes.

Study title and authors:
Effects of four different meal types on the population pharmacokinetics of single-dose rifapentine in healthy male volunteers.

Zvada SP, Van Der Walt JS, Smith PJ, Fourie PB, Roscigno G, Mitchison D, Simonsson US, McIlleron HM.

Books:

Division of Clinical Pharmacology, K-45 Old Main Building, Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa.

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/20516273

Rifapentine is an antibiotic drug used in the treatment of tuberculosis.

The study measured the effect of four different meals on rifapentine oral bioavailability. The meals were:
high fat (meal A), (English breakfast)
bulk and low fat (meal B), (maize meal porridge)
bulk and high fat (meal C), (maize meal porridge with lard)
high fluid and low fat (meal D) (chicken noodle soup)

Compared with the fasting state meal A (English breakfast, which included bacon, fried eggs, butter and full-cream milk) had the greatest effect on rifapentine oral bioavailability, increasing it by 86%.

The lowest effect was in meal B (maize meal porridge) which only registered a 33% increase. However when lard was added to the maize meal porridge, bioavailability increased to 46%.

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Recipe of the day

Fried Eggs and Bacon with Sliced Grape Tomatoes

Ingredient list:

Food Mall: Eggs

Three strips of bacon (nitrate, dairy, gluten, casein, sugar-free)

Three fresh eggs
15 grape tomatoes
Black pepper
Salt

Directions:
Add bacon to cold skillet and set heat to low. Bacon does not curl when added to a cold skillet and cooks best over low heat. Turn bacon frequently and allow browning to desired level of crispiness, which for me takes 3-4 minutes. Remove bacon to a paper towel to soak up excess grease. Crack three eggs into the hot bacon grease in skillet. Salt and pepper to taste. Pierce yolks with a spatula to ensure even cooking. Add sliced tomatoes across eggs as they are cooking. Turn eggs with spatula to insure that all parts have cooked well. Transfer to plate and add bacon on the side.



Vitamin D deficiency and susceptibility to tuberculosis

This post includes a synopsis of a study published in Calcified Tissue International 2000 Jun;66(6):476-8 and a recipe for scrambled eggs.

Study title and author:
Vitamin D deficiency and susceptibility to tuberculosis.
Chan TY.                                                                                                                            Books:

Division of Clinical Pharmacology, Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong.

This paper can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/10821887
 
The author observes that vitamin D deficiency is associated with a higher risk of tuberculosis, such as with people with low serum vitamin D levels e.g. the elderly and patients with kidney disease.
 
The richest dietary sources of vitamin D include: butterfat, lard, eggs, liver, organ meats, marine oils and seafood.
 
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Recipe of the day
                                                                                                                             Food Mall: Eggs

Scrambled Eggs

 

Ingredients:

- Fresh eggs

Instructions:
- Scramble desired number of eggs in lard.