Statin use increases the risk of osteoarthritis and joint pain by 26%

This study was published in the American Journal of Medical Sciences 2013 May;345(5):343-8

 

Study title and authors:

Incidence of musculoskeletal and neoplastic diseases in patients on statin therapy: results of a retrospective cohort analysis.

Mansi IA, Mortensen EM, Pugh MJ, Wegner M, Frei CR.

Brooke Army Medical Center, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78234-6200, USA. Iishak.mansi@us.army.mil

 

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/22975580

This study was conducted to investigate the incidence of various musculoskeletal diseases in statin users and nonusers. The study included 12,980 statin users and 45,997 nonusers who were followed for four years.

The study found:
(a) Statin users had a 26% increased risk of osteoarthritis and arthropathy (joint pain) compared to non-users.
(b) Statin users had a 20% increased risk of dorsopathies (back or spinal pain), rheumatism (joint and connective tissue problems) and chondropathies (cartilage disease) compared to non-users.

Statin users suffer from significantly more musculoskeletal pain

This study was published in the Journal of General Internal Medicine 2008 Aug;23(8):1182-6

Study title and authors:
Prevalence of musculoskeletal pain and statin use.

Buettner C, Davis RB, Leveille SG, Mittleman MA, Mukamal KJ.
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA. cbuettne@bidmc.harvard.edu

This study can be accessed at: http://www.ncbi.nlm.nih.gov/pubmed/18449611

This study sought to evaluate whether statin use was associated with a higher prevalence of musculoskeletal pain. The study included 3,580 participants, aged 40 or over, without arthritis.

The study found:
(a) Compared to persons who did not use statins, those who used statins had a 50% increased risk for any musculoskeletal pain.
(b) Compared to persons who did not use statins, those who used statins had a 59% increased risk for lower back pain.
(c) Compared to persons who did not use statins, those who used statins had a 50% increased risk for lower extremity pain.

This study finds that statin users are significantly more likely to report musculoskeletal pain compared to persons who did not use statins.